Immunotropic funds

Application immunotropic means and methods to slow aging is based on the hypothesis linking aging with aging the immune system, and above all with the involution of the thymus in humans and animals. There is evidence that hormonal substance of the thymus (thymic humoral factor, timopoetin, thymosin, and others), and interleukin-2, izoprinozin, immunotsital, LPS (immune) azatiprin (immunosuppressant), and timeks timalin (thymus extract) and other slow involution of the thymus, have a normalizing effect on the functions of various systems, prevent tumors, stimulate the body's defenses, but no appreciable effect on the aging process.

For example, the effects of immunomodulators and thymalin epithalamin to 3.5 months in rats increased the forthcoming life expectancy and maximum life span is mainly due to reduction of tumors. Older people both drugs act on the central mechanisms (peptidergic) regulation, providing a normalizing effect on the immune, neuroendocrine and urogenital system. There is a report that in rats the peptide immunomodulator thymogen caused an increase in the maximum duration of animal life from 946 to 1048 days, while life expectancy has not changed, although the drug helped to slow the development of tumors (Paveleva IA, 1991). These data require validation.

T. Makinodan carried transplantation of the thymus and bone marrow from young mice, old. The author reported that this was happening, "rejuvenation" of the immune system and prolong the life of animals. Other researchers have indicated that multiple thymus transplantation in older age (aging) are ineffective, and multiple long-lived mice with transplants of lines in the period of puberty the thymus gland of newborn mice slowed the decrease in T-dependent immune function and development of the disease, with an average life expectancy increased, and maximum life span is not changed. The new interest in the problem associated with the works of VI Dontsova (1992-2000), indicating the central role of T lymphocytes in the development and aging.