Limitation of power

This anti-aging method is currently considered the most promising. Apparently, the first systematic experiments were conducted on mammals T. Osborne (1915)). Even then, in experiments on rats found that calorie - restricted (20-30%) complete diet caused a significant prolongation of animal life.

In 1930-43 he. Intensive research carried out by teams McKay, then M. Ross, C. Burrows, V. Nikitin, A. Everittt and others. In all the experiments described an increase in life expectancy of 40-100% under the influence of different conditions of food restriction and dietary restrictions, even a single amino acid - tryptophan. Characteristically, the experimental animals in adulthood long retained signs typical of the young. Most able to slow aging in those experiments where the effect began at an early age. Restricting supply in mature and late instars were ineffective. Some authors have reported lower mortality of animals in the later stages of life and increased mortality at younger ages. In recent years an increasing number of studies in which there was only a slight increase in the maximum life expectancy, especially in experiments on long-lived lines of mice and rats. Analysis of the array of works carried out before 1980, which included 195 groups of animals showed that the effects of calorie - restricted diet in all experiments, the average life expectancy and maximum life span increased by an average of 15 and 16% respectively, with a large spread values of life on both sides of these averages.

Restricting food is a biological way of prolonging life, as this effect constrains the growth of young animals and alter their software development in a manner that the effect of slowing the aging manifests itself in adulthood and old age. IA Arshavskii shown that hungry rats during puberty may increase by 3 times. Our analysis of published data on life expectancy and duration of puberty in 200 species from 14 orders of mammals has shown that between these parameters is a clear correlation. This, in particular, can be explained by the prolongation of life of animals in experiments with limited supply. The National Toxicology Laboratory, USA, an experiment with fasting for 30 thousand rats and mice (1990). It is established that the animals decreased metabolism and body temperature. Characteristically there was some decrease in the average life expectancy of control over the average life expectancy of intact animals, and life expectancy has increased in the experimental versus control. L. Hayflick observed that experimental animals do not live an unusually long time. Just checking, will move more quickly grow old and live shorter lives. It is not excluded that in these experiments, starvation is a factor in reducing body temperature and metabolism, which occurs under the influence of growth retardation, changes in the development process and slowing down aging. It is well known that the 3-day fasting in adult rats the temperature can drop to room temperature.

Characterized by retardation of aging in the 2nd half of life of experimental animals, even without power during this period. It can be assumed that the restriction of supply by itself practically does not change the rate of aging, but when working on a program of animal development at an early age, qualitatively alters the metabolism in later life. The increase in life expectancy is usually observed in rats and mice, which develop before puberty is very labile with limited power (delay of growth and sexual maturation, decreased metabolism and body temperature).

In other species (rabbits, dogs, monkeys) these changes are less pronounced. Such changes in the program of human development is not found, but during starvation the body temperature is slightly reduced. As regards the level of metabolism, there is reason to expect that it will increase. If a similar phenomenon will occur in humans until puberty, then starvation during this period can even lead to a reduction in later life. Because this way of life extension requires careful study. Furthermore, calorie-deficient diet, according to some regions of the globe, leading to profound metabolic disorders, especially in the early human causes irreversible structural changes in the CNS, leading to a reduction in life. The elderly poor nutrition contributes to the development of hypothermia in the winter and an increase in injuries.

There are reports that 5-fold decrease in the amount of tryptophan in the diet increased the life expectancy of rats by 20%. This changes the content of serotonin in the brain, indicating that the restructuring of parts of the central regulation of change in the balance neurotransmitters in the hypothalamus.

The significant decrease of tryptophan in the diet of a person at an early age may be accompanied by a violation of the processes of growth, protein metabolism and the development of pellagra.

Some extension of human life by limiting supply can be achieved under the influence of the second half of life. This is confirmed by numerous data longevity of people. Here, apparently, food restriction slows age-related changes are not due to decrease metabolism, and by mitigating the stress of the metabolic changes characteristic of aging. It is important that the food was limited and full.